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Contrave can be a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, which may make them more potent and safer. Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that as of right now there are no long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. 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